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Venous thromboembolism

DOID EFO Endpoint Browser PheWeb

I9_VTE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I26, I80, O87.1, O88.2
  • Hospital discharge: ICD-9 — 415|451|6713|6714|6732
  • Hospital discharge: ICD-8 — 450|451|671|6739
  • Hospital discharge: excluded ICD-10 — I80.0#
  • Hospital discharge: excluded ICD-9 — 4510
  • Cause of death: ICD-10 — I26, I80, O87.1, O88.2
  • Cause of death: ICD-9 — 415|451|6713|6714|6732
  • Cause of death: ICD-8 — 450|451|671|6739
  • Cause of death: excluded ICD-10 — I80.0#
  • Cause of death: excluded ICD-9 — 4510

2 out of 7 registries used, show all original rules.

24196

4. Check minimum number of events

None

24196

5. Include endpoints

None

24196

6. Filter based on genotype QC (FinnGen only)

23367

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 248674 138776 106624
Only index persons 178972 102819 76153
Unadjusted period prevalence (%)
Whole population 3.54 3.97 2.98
Only index persons 3.41 3.78 2.91
Median age at first event (years)
Whole population 65.14 66.44 63.36
Only index persons 62.36 63.33 61.06

-FinnGen-

Key figures

All Female Male
Number of individuals 23367 12524 10843
Unadjusted period prevalence (%) 5.16 4.92 5.45
Median age at first event (years) 60.20 57.80 62.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_VTE and mortality.

Females

Parameter HR [95% CI] p-value
I9_VTE 2.165 [1.99, 2.36] < 0.001
Birth year 0.993 [0.99, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 32766 out of 80974 females with I9_VTE died.

Males

Parameter HR [95% CI] p-value
I9_VTE 2.234 [2.03, 2.46] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 24507 out of 61597 males with I9_VTE died.

Mortality risk

Mortality risk for people of age

years, who have I9_VTE.

N-year risk Females Males
1 0.205% 0.471%
5 1.27% 2.114%
10 2.873% 5.435%
15 5.339% 10.021%
20 9.226% 17.1%

Relationships between endpoints

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Index endpoint: I9_VTE – Venous thromboembolism

GWS hits: 50

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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