No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7470 |
4. Check minimum number of eventsNone |
7470 |
5. Include endpointsNone |
7470 |
6. Filter based on genotype QC (FinnGen only) |
7216 |
Control definitions (FinnGen only)
Control exclude
I9_DISVEINLYMPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF10
Similar endpoints
↥List of similar endpoints to
DVT of lower extremities
based on the number of shared cases.
Similar with more cases:
- DVT of lower extremities and pulmonary embolism
- Venous thromboembolism
- Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (FINNGEN)
- Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 75938 | 40582 | 34466 |
| Only index persons | 57445 | 31327 | 26118 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.07 | 1.16 | 0.96 |
| Only index persons | 1.08 | 1.15 | 1.00 |
| Median age at first event (years) | |||
| Whole population | 64.23 | 66.20 | 61.83 |
| Only index persons | 61.18 | 62.72 | 59.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7216 | 3716 | 3500 |
| Unadjusted period prevalence (%) | 1.60 | 1.46 | 1.76 |
| Median age at first event (years) | 58.86 | 56.99 | 60.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_PHLETHROMBDVTLOW and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_PHLETHROMBDVTLOW | 1.956 [1.79, 2.14] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 8481 out of 23064 females with I9_PHLETHROMBDVTLOW died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_PHLETHROMBDVTLOW | 1.787 [1.62, 1.97] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 6539 out of 19493 males with I9_PHLETHROMBDVTLOW died.
Mortality risk
Mortality risk for people of age
years, who have I9_PHLETHROMBDVTLOW.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.157% | 0.291% |
| 5 | 1.053% | 1.943% |
| 10 | 2.745% | 4.865% |
| 15 | 5.114% | 9.035% |
| 20 | 9.384% | 15.535% |
Relationships between endpoints
↥Index endpoint: I9_PHLETHROMBDVTLOW – DVT of lower extremities
GWS hits: 20
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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