vascular disease: A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma.
Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
I9_DISVEINLYMPH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
62858 |
6. Filter based on genotype QC (FinnGen only) |
60873 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 600788 | 400004 | 196249 |
| Only index persons | 501928 | 341484 | 160444 |
| Unadjusted period prevalence (%) | |||
| Whole population | 9.45 | 11.46 | 5.48 |
| Only index persons | 10.50 | 12.55 | 6.12 |
| Median age at first event (years) | |||
| Whole population | 50.16 | 48.61 | 53.16 |
| Only index persons | 48.06 | 46.61 | 51.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 60873 | 40348 | 20525 |
| Unadjusted period prevalence (%) | 13.98 | 15.85 | 10.31 |
| Median age at first event (years) | 47.70 | 44.32 | 54.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_DISVEINLYMPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISVEINLYMPH | 1.607 [1.48, 1.75] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 31662 out of 161649 females with I9_DISVEINLYMPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISVEINLYMPH | 1.762 [1.61, 1.92] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 27955 out of 106317 males with I9_DISVEINLYMPH died.
Mortality risk
Mortality risk for people of age
years, who have I9_DISVEINLYMPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.277% |
| 5 | 0.831% | 1.788% |
| 10 | 2.054% | 4.524% |
| 15 | 4.137% | 8.515% |
| 20 | 7.098% | 13.951% |
Relationships between endpoints
↥Index endpoint: I9_DISVEINLYMPH – Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
GWS hits: 134
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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