≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other noninfective disorders of lymphatic vessels and lymph nodes

DOID EFO Endpoint Browser PheWeb

I9_LYMPHOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I89
  • Hospital discharge: ICD-9 — 457
  • Hospital discharge: ICD-8 — 457
  • Cause of death: ICD-10 — I89
  • Cause of death: ICD-9 — 457
  • Cause of death: ICD-8 — 457

2 out of 7 registries used, show all original rules.

1163

4. Check minimum number of events

None

1163

5. Include endpoints

None

1163

6. Filter based on genotype QC (FinnGen only)

1132

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Aliae morbositates non infectiosae vasorum et nodorum lymphaticorum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9748 5979 3698
Only index persons 8497 5284 3213
Unadjusted period prevalence (%)
Whole population 0.14 0.17 0.10
Only index persons 0.17 0.19 0.12
Median age at first event (years)
Whole population 56.39 58.40 53.03
Only index persons 55.00 56.91 51.85

-FinnGen-

Key figures

All Female Male
Number of individuals 1132 769 363
Unadjusted period prevalence (%) 0.26 0.30 0.18
Median age at first event (years) 56.65 55.45 59.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint I9_LYMPHOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_LYMPHOTH 1.951 [1.71, 2.23] < 0.001
Birth year 0.993 [0.98, 1.0] 0.118

During the follow-up period (1.1.1998 — 31.12.2019), 1067 out of 4362 females with I9_LYMPHOTH died.

Males

Parameter HR [95% CI] p-value
I9_LYMPHOTH 2.324 [1.96, 2.76] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 702 out of 2784 males with I9_LYMPHOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_LYMPHOTH.

N-year risk Females Males
1 0.183% 0.446%
5 1.15% 2.746%
10 3.003% 6.869%
15 5.467% 12.824%
20 9.696% 21.8%

Relationships between endpoints

↥

Index endpoint: I9_LYMPHOTH – Other noninfective disorders of lymphatic vessels and lymph nodes

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data