vascular disease: A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
16447 |
4. Check minimum number of eventsNone |
16447 |
5. Include endpointsNone |
16447 |
6. Filter based on genotype QC (FinnGen only) |
15929 |
Control definitions (FinnGen only)
Control exclude
I9_DISVEINLYMPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
I80-I89
Name in latin
Aliae morbositates venarum
Similar endpoints
↥List of similar endpoints to
Other disorders of veins
based on the number of shared cases.
Similar with more cases:
- Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 105015 | 73381 | 31243 |
| Only index persons | 102237 | 72023 | 30214 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.73 | 2.10 | 0.87 |
| Only index persons | 2.21 | 2.65 | 1.15 |
| Median age at first event (years) | |||
| Whole population | 58.91 | 58.48 | 60.05 |
| Only index persons | 58.68 | 58.23 | 59.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15929 | 11400 | 4529 |
| Unadjusted period prevalence (%) | 3.85 | 4.48 | 2.27 |
| Median age at first event (years) | 58.70 | 57.09 | 62.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_VEINSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VEINSOTH | 1.118 [1.0, 1.24] | 0.042 |
| Birth year | 0.995 [0.99, 1.0] | 0.222 |
During the follow-up period (1.1.1998 — 31.12.2019), 6920 out of 61720 females with I9_VEINSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VEINSOTH | 1.324 [1.07, 1.64] | 0.01 |
| Birth year | 0.985 [0.94, 1.04] | 0.558 |
During the follow-up period (1.1.1998 — 31.12.2019), 4392 out of 25706 males with I9_VEINSOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_VEINSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.224% |
| 5 | 0.595% | 1.474% |
| 10 | 1.496% | 3.786% |
| 15 | 2.943% | 6.714% |
| 20 | 5.199% | 11.253% |
Relationships between endpoints
↥Index endpoint: I9_VEINSOTH – Other disorders of veins
GWS hits: 40
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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