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Nonspecific lymphadenitis

DOID EFO Endpoint Browser PheWeb

I9_LYMPHADE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I88
  • Hospital discharge: ICD-9 — 289[1-2]
  • Hospital discharge: ICD-8 — 289[1-3]
  • Cause of death: ICD-10 — I88
  • Cause of death: ICD-9 — 289[1-2]
  • Cause of death: ICD-8 — 289[1-3]

2 out of 7 registries used, show all original rules.

2286

4. Check minimum number of events

None

2286

5. Include endpoints

None

2286

6. Filter based on genotype QC (FinnGen only)

2227

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Lymphadenitis non specifica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21458 12186 9189
Only index persons 19301 11160 8141
Unadjusted period prevalence (%)
Whole population 0.31 0.35 0.26
Only index persons 0.37 0.41 0.31
Median age at first event (years)
Whole population 18.15 19.68 16.00
Only index persons 17.89 19.42 15.79

-FinnGen-

Key figures

All Female Male
Number of individuals 2227 1485 742
Unadjusted period prevalence (%) 0.51 0.58 0.37
Median age at first event (years) 19.77 19.67 19.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_LYMPHADE and mortality.

Females

Parameter HR [95% CI] p-value
I9_LYMPHADE 1.61 [1.34, 1.93] < 0.001
Birth year 0.998 [0.99, 1.01] 0.571

During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 3491 females with I9_LYMPHADE died.

Males

Parameter HR [95% CI] p-value
I9_LYMPHADE 1.931 [1.62, 2.3] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 3230 males with I9_LYMPHADE died.

Mortality risk

Mortality risk for people of age

years, who have I9_LYMPHADE.

N-year risk Females Males
1 0.154% 0.251%
5 0.839% 1.932%
10 2.414% 5.144%
15 4.555% 10.168%
20 8.072% 16.551%

Relationships between endpoints

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Index endpoint: I9_LYMPHADE – Nonspecific lymphadenitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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