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Varicose veins of other sites

DOID EFO Endpoint Browser PheWeb

I9_VARICVESOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I86
  • Hospital discharge: ICD-9 — 456
  • Hospital discharge: ICD-8 — 456
  • Hospital discharge: excluded ICD-9 — 456[0-1]
  • Hospital discharge: excluded ICD-8 — 4560
  • Cause of death: ICD-10 — I86
  • Cause of death: ICD-9 — 456
  • Cause of death: ICD-8 — 456
  • Cause of death: excluded ICD-9 — 456[0-1]
  • Cause of death: excluded ICD-8 — 4560

2 out of 7 registries used, show all original rules.

2379

4. Check minimum number of events

None

2379

5. Include endpoints

None

2379

6. Filter based on genotype QC (FinnGen only)

2290

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Venae varicosae aliis locis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21994 4944 16902
Only index persons 20552 4562 15990
Unadjusted period prevalence (%)
Whole population 0.40 0.14 0.47
Only index persons 0.51 0.17 0.61
Median age at first event (years)
Whole population 32.04 43.79 28.56
Only index persons 31.33 42.99 28.00

-FinnGen-

Key figures

All Female Male
Number of individuals 2290 759 1531
Unadjusted period prevalence (%) 0.61 0.30 0.77
Median age at first event (years) 36.98 42.45 34.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_VARICVESOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_VARICVESOTH 1.4 [1.19, 1.65] < 0.001
Birth year 1.0 [0.99, 1.01] 0.956

During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 2072 females with I9_VARICVESOTH died.

Males

Parameter HR [95% CI] p-value
I9_VARICVESOTH 1.219 [1.07, 1.39] 0.003
Birth year 0.983 [0.97, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 705 out of 9332 males with I9_VARICVESOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_VARICVESOTH.

N-year risk Females Males
1 0.167% 0.193%
5 0.965% 1.245%
10 2.371% 3.177%
15 4.701% 5.973%
20 7.766% 10.185%

Relationships between endpoints

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Index endpoint: I9_VARICVESOTH – Varicose veins of other sites

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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