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Portal vein thrombosis

DOID EFO Endpoint Browser PheWeb

I9_PVT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I81
  • Hospital discharge: ICD-9 — 452
  • Hospital discharge: ICD-8 — 452
  • Cause of death: ICD-10 — I81
  • Cause of death: ICD-9 — 452
  • Cause of death: ICD-8 — 452

2 out of 7 registries used, show all original rules.

459

4. Check minimum number of events

None

459

5. Include endpoints

None

459

6. Filter based on genotype QC (FinnGen only)

440

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Thrombosis venae portae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3823 1578 2210
Only index persons 3061 1272 1789
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.06
Only index persons 0.06 0.05 0.07
Median age at first event (years)
Whole population 62.20 62.36 62.10
Only index persons 61.19 60.50 61.68

-FinnGen-

Key figures

All Female Male
Number of individuals 440 188 252
Unadjusted period prevalence (%) 0.10 0.07 0.13
Median age at first event (years) 61.55 59.67 62.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_PVT and mortality.

Females

Parameter HR [95% CI] p-value
I9_PVT 2.849 [2.24, 3.63] < 0.001
Birth year 0.997 [0.99, 1.01] 0.487

During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 988 females with I9_PVT died.

Males

Parameter HR [95% CI] p-value
I9_PVT 4.077 [3.25, 5.12] < 0.001
Birth year 0.987 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 649 out of 1429 males with I9_PVT died.

Mortality risk

Mortality risk for people of age

years, who have I9_PVT.

N-year risk Females Males
1 0.295% 0.843%
5 1.882% 4.944%
10 4.634% 12.337%
15 8.574% 21.809%
20 14.689% 34.055%

Relationships between endpoints

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Index endpoint: I9_PVT – Portal vein thrombosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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