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Oesophageal varices

DOID EFO Endpoint Browser PheWeb

I9_VARICVEOES

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I85
  • Hospital discharge: ICD-9 — 456[0-1]
  • Hospital discharge: ICD-8 — 4560
  • Cause of death: ICD-10 — I85
  • Cause of death: ICD-9 — 456[0-1]
  • Cause of death: ICD-8 — 4560

2 out of 7 registries used, show all original rules.

1293

4. Check minimum number of events

None

1293

5. Include endpoints

None

1293

6. Filter based on genotype QC (FinnGen only)

1243

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Varices oesophagi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15571 4582 10653
Only index persons 9567 3029 6538
Unadjusted period prevalence (%)
Whole population 0.25 0.13 0.30
Only index persons 0.21 0.11 0.25
Median age at first event (years)
Whole population 59.23 62.25 57.96
Only index persons 60.61 62.62 59.68

-FinnGen-

Key figures

All Female Male
Number of individuals 1243 434 809
Unadjusted period prevalence (%) 0.32 0.17 0.41
Median age at first event (years) 62.53 62.82 62.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_VARICVEOES and mortality.

Females

Parameter HR [95% CI] p-value
I9_VARICVEOES 8.066 [6.74, 9.65] < 0.001
Birth year 0.99 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 1624 out of 2914 females with I9_VARICVEOES died.

Males

Parameter HR [95% CI] p-value
I9_VARICVEOES 9.18 [7.92, 10.63] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3955 out of 6272 males with I9_VARICVEOES died.

Mortality risk

Mortality risk for people of age

years, who have I9_VARICVEOES.

N-year risk Females Males
1 0.878% 1.631%
5 4.186% 9.69%
10 10.017% 21.728%
15 18.217% 37.731%
20 30.053% 54.018%

Relationships between endpoints

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Index endpoint: I9_VARICVEOES – Oesophageal varices

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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