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Phlebitis and thrombophlebitis (not including DVT)

DOID EFO Endpoint Browser PheWeb

I9_PHLETHROM

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I80
  • Hospital discharge: ICD-9 — 4519X|4518X
  • Hospital discharge: ICD-8 — 451
  • Hospital discharge: excluded ICD-10 — I80.20#, I80.29#, I80.3#
  • Hospital discharge: excluded ICD-8 — 4510
  • Cause of death: ICD-10 — I80
  • Cause of death: ICD-9 — 4519X|4518X
  • Cause of death: ICD-8 — 451
  • Cause of death: excluded ICD-10 — I80.20#, I80.29#, I80.3#
  • Cause of death: excluded ICD-8 — 4510

2 out of 7 registries used, show all original rules.

8924

4. Check minimum number of events

None

8924

5. Include endpoints

None

8924

6. Filter based on genotype QC (FinnGen only)

8602

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Phlebitis et thrombophlebitis

Similar endpoints

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List of similar endpoints to Phlebitis and thrombophlebitis (not including DVT) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 71773 42313 29016
Only index persons 64610 38528 26082
Unadjusted period prevalence (%)
Whole population 1.05 1.21 0.81
Only index persons 1.25 1.42 1.00
Median age at first event (years)
Whole population 61.90 62.83 60.49
Only index persons 60.82 61.61 59.64

-FinnGen-

Key figures

All Female Male
Number of individuals 8602 5078 3524
Unadjusted period prevalence (%) 1.90 1.99 1.77
Median age at first event (years) 58.62 56.74 61.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_PHLETHROM and mortality.

Females

Parameter HR [95% CI] p-value
I9_PHLETHROM 1.834 [1.67, 2.01] < 0.001
Birth year 0.994 [0.99, 1.0] 0.177

During the follow-up period (1.1.1998 — 31.12.2019), 9742 out of 34842 females with I9_PHLETHROM died.

Males

Parameter HR [95% CI] p-value
I9_PHLETHROM 1.749 [1.58, 1.94] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 6754 out of 23525 males with I9_PHLETHROM died.

Mortality risk

Mortality risk for people of age

years, who have I9_PHLETHROM.

N-year risk Females Males
1 0.167% 0.274%
5 1.093% 1.634%
10 2.694% 4.257%
15 5.047% 8.003%
20 8.804% 13.049%

Relationships between endpoints

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Index endpoint: I9_PHLETHROM – Phlebitis and thrombophlebitis (not including DVT)

GWS hits: 12

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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