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Other embolism and thrombosis

DOID EFO Endpoint Browser PheWeb

I9_THROMBOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I82
  • Hospital discharge: ICD-9 — 453
  • Hospital discharge: ICD-8 — 453
  • Cause of death: ICD-10 — I82
  • Cause of death: ICD-9 — 453
  • Cause of death: ICD-8 — 453

2 out of 7 registries used, show all original rules.

4910

4. Check minimum number of events

None

4910

5. Include endpoints

None

4910

6. Filter based on genotype QC (FinnGen only)

4732

Control definitions (FinnGen only)

Control exclude I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I80-I89
Name in latin Embolia/thrombosis aliarum venarum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 46470 24889 21094
Only index persons 36168 19955 16213
Unadjusted period prevalence (%)
Whole population 0.65 0.71 0.59
Only index persons 0.68 0.73 0.62
Median age at first event (years)
Whole population 61.87 62.98 60.47
Only index persons 59.43 60.32 58.34

-FinnGen-

Key figures

All Female Male
Number of individuals 4732 2592 2140
Unadjusted period prevalence (%) 1.04 1.02 1.07
Median age at first event (years) 57.32 54.94 60.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_THROMBOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_THROMBOTH 2.119 [1.92, 2.33] < 0.001
Birth year 0.992 [0.98, 1.0] 0.068

During the follow-up period (1.1.1998 — 31.12.2019), 5767 out of 16183 females with I9_THROMBOTH died.

Males

Parameter HR [95% CI] p-value
I9_THROMBOTH 2.041 [1.84, 2.27] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 4604 out of 13349 males with I9_THROMBOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_THROMBOTH.

N-year risk Females Males
1 0.179% 0.358%
5 1.028% 2.304%
10 2.639% 5.249%
15 5.374% 10.098%
20 9.262% 17.256%

Relationships between endpoints

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Index endpoint: I9_THROMBOTH – Other embolism and thrombosis

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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