No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
35574 |
4. Check minimum number of eventsNone |
35574 |
5. Include endpointsNone |
35574 |
6. Filter based on genotype QC (FinnGen only) |
34542 |
Control definitions (FinnGen only)
Control exclude
I9_DISVEINLYMPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I80-I89
Name in latin
Varices membrorum inferiorum
Similar endpoints
↥List of similar endpoints to
Varicose veins
based on the number of shared cases.
Similar with more cases:
- Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (FINNGEN)
- Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 363367 | 277729 | 83293 |
| Only index persons | 301989 | 235312 | 66677 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.63 | 7.95 | 2.33 |
| Only index persons | 7.30 | 8.65 | 2.55 |
| Median age at first event (years) | |||
| Whole population | 47.94 | 46.71 | 51.83 |
| Only index persons | 46.04 | 44.90 | 50.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 34542 | 25561 | 8981 |
| Unadjusted period prevalence (%) | 8.60 | 10.04 | 4.51 |
| Median age at first event (years) | 44.23 | 41.93 | 50.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_VARICVE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VARICVE | 1.201 [1.11, 1.3] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.154 |
During the follow-up period (1.1.1998 — 31.12.2019), 13569 out of 81126 females with I9_VARICVE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VARICVE | 1.353 [1.25, 1.46] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 9441 out of 36537 males with I9_VARICVE died.
Mortality risk
Mortality risk for people of age
years, who have I9_VARICVE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.249% |
| 5 | 0.673% | 1.642% |
| 10 | 1.582% | 3.913% |
| 15 | 3.14% | 7.079% |
| 20 | 5.497% | 11.948% |
Relationships between endpoints
↥Index endpoint: I9_VARICVE – Varicose veins
GWS hits: 159
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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