cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4983 |
6. Filter based on genotype QC (FinnGen only) |
4845 |
Control definitions (FinnGen only)
Control exclude
FG_OTHHEART
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy (excluding other)
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 44956 | 11872 | 32437 |
| Only index persons | 32361 | 8972 | 23389 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.75 | 0.34 | 0.91 |
| Only index persons | 0.74 | 0.33 | 0.89 |
| Median age at first event (years) | |||
| Whole population | 61.62 | 64.77 | 60.42 |
| Only index persons | 61.62 | 64.02 | 60.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4845 | 1321 | 3524 |
| Unadjusted period prevalence (%) | 1.43 | 0.52 | 1.77 |
| Median age at first event (years) | 61.44 | 60.52 | 61.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint FG_CARDMYO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_CARDMYO | 2.852 [2.59, 3.15] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 3005 out of 8180 females with FG_CARDMYO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_CARDMYO | 3.025 [2.76, 3.32] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 9127 out of 21265 males with FG_CARDMYO died.
Mortality risk
Mortality risk for people of age
years, who have FG_CARDMYO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.255% | 0.477% |
| 5 | 1.473% | 2.783% |
| 10 | 3.625% | 6.932% |
| 15 | 6.938% | 13.45% |
| 20 | 11.72% | 21.585% |
Relationships between endpoints
↥Index endpoint: FG_CARDMYO – Cardiomyopathy (excluding other)
GWS hits: 15
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data