cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
195 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathies, Secondary/extrinsic
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4781 | 746 | 3926 |
| Only index persons | 2094 | 381 | 1713 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.02 | 0.11 |
| Only index persons | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 56.51 | 59.10 | 55.87 |
| Only index persons | 58.60 | 60.45 | 58.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 195 | 58 | 137 |
| Unadjusted period prevalence (%) | 0.06 | 0.02 | 0.07 |
| Median age at first event (years) | 59.78 | 54.59 | 61.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMSEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 6.432 [4.18, 9.9] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 233 females with I9_CARDMSEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 7.233 [5.83, 8.98] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 480 out of 782 males with I9_CARDMSEC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMSEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.612% | 1.675% |
| 5 | 3.985% | 8.275% |
| 10 | 9.404% | 18.906% |
| 15 | 17.163% | 33.051% |
| 20 | 27.778% | 49.542% |
Relationships between endpoints
↥Index endpoint: I9_CARDMSEC – Cardiomyopathies, Secondary/extrinsic
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data