No definition available.
Cardiomyopathy due to drugs and other external agents
CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
63 |
4. Check minimum number of eventsNone |
63 |
5. Include endpointsNone |
63 |
6. Filter based on genotype QC (FinnGen only) |
62 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy due to drugs and other external agents
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathies, Secondary/extrinsic
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 370 | 194 | 172 |
| Only index persons | 288 | 154 | 134 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.64 | 60.72 | 56.11 |
| Only index persons | 57.79 | 60.94 | 54.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 62 | 42 | 20 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 59.10 | 56.45 | 64.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS | 5.804 [3.29, 10.24] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 160 females with CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS | 4.335 [2.25, 8.34] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 136 males with CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS died.
Mortality risk
Mortality risk for people of age
years, who have CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.329% | 0.929% |
| 5 | 2.531% | 5.604% |
| 10 | 7.054% | 13.748% |
| 15 | 13.192% | 25.687% |
| 20 | 21.35% | 40.197% |
Relationships between endpoints
↥Index endpoint: CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS – Cardiomyopathy due to drugs and other external agents
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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