cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
6739 |
4. Check minimum number of eventsNone |
6739 |
5. Include endpoints |
7111 |
6. Filter based on genotype QC (FinnGen only) |
6907 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I30-I52
Name in latin
Cardiomyopathia
Cardiomyopathy
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 64595 | 19959 | 43679 |
| Only index persons | 45919 | 15193 | 30726 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.02 | 0.57 | 1.22 |
| Only index persons | 0.97 | 0.56 | 1.17 |
| Median age at first event (years) | |||
| Whole population | 61.32 | 64.86 | 59.69 |
| Only index persons | 61.74 | 64.65 | 60.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6907 | 2291 | 4616 |
| Unadjusted period prevalence (%) | 1.85 | 0.90 | 2.32 |
| Median age at first event (years) | 61.37 | 60.96 | 61.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYO | 2.494 [2.27, 2.74] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.212 |
During the follow-up period (1.1.1998 — 31.12.2019), 4442 out of 13050 females with I9_CARDMYO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYO | 2.801 [2.55, 3.08] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 10866 out of 26799 males with I9_CARDMYO died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.299% | 0.505% |
| 5 | 1.513% | 2.841% |
| 10 | 3.438% | 7.203% |
| 15 | 6.214% | 13.511% |
| 20 | 11.01% | 22.488% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYO – Cardiomyopathy
GWS hits: 19
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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