cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
151 |
4. Check minimum number of eventsNone |
151 |
5. Include endpointsNone |
151 |
6. Filter based on genotype QC (FinnGen only) |
148 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy in other diseases
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Other heart diseases
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 549 | 728 |
| Only index persons | 1090 | 458 | 632 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 75.24 | 77.02 | 73.83 |
| Only index persons | 75.15 | 76.96 | 73.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 148 | 56 | 92 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 73.07 | 71.36 | 74.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 2.876 [2.14, 3.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.266 |
During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 468 females with I9_CARDMYOINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 3.006 [2.13, 4.25] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 575 males with I9_CARDMYOINOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.544% |
| 5 | 1.524% | 3.482% |
| 10 | 4.342% | 8.284% |
| 15 | 8.369% | 15.119% |
| 20 | 14.153% | 24.199% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOINOTH – Cardiomyopathy in other diseases
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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