Alcoholic cardiomyopathy

I9_CARDMYOALC

alcoholic cardiomyopathy: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I42.6
  • Hospital discharge: ICD-9 4255A
  • Cause of death: ICD-10 I42.6
  • Cause of death: ICD-9 4255A

2 out of 7 registries used, show all original rules.

152

4. Check minimum number of events

None

152

5. Include endpoints

None

152

6. Filter based on genotype QC (FinnGen only)

147

Control definitions (FinnGen only)

Control exclude I9_CARDMYO

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I42
Name in latin Cardiomyopathia alcoholica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5527 579 4785
Only index persons 1818 218 1600
Unadjusted period prevalence (%)
Whole population 0.12 0.02 0.13
Only index persons 0.05 0.01 0.06
Median age at first event (years)
Whole population 54.66 56.03 54.42
Only index persons 58.18 59.42 58.01

-FinnGen-

Key figures

All Female Male
Number of individuals 147 13 134
Unadjusted period prevalence (%) 0.06 0.01 0.07
Median age at first event (years) 60.82 48.78 61.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint I9_CARDMYOALC and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
I9_CARDMYOALC 8.396 [6.95, 10.14] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 630 males with I9_CARDMYOALC died.

Mortality risk

Mortality risk for people of age

years, who have I9_CARDMYOALC.

N-year risk Females Males
1 No data 1.353%
5 No data 8.938%
10 No data 20.736%
15 No data 36.196%
20 No data 53.948%

Relationships between endpoints

Index endpoint: I9_CARDMYOALC – Alcoholic cardiomyopathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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