alcoholic cardiomyopathy: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
152 |
4. Check minimum number of eventsNone |
152 |
5. Include endpointsNone |
152 |
6. Filter based on genotype QC (FinnGen only) |
147 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Alcoholic cardiomyopathy based on the number of shared cases.
Similar with more cases:
- Alcoholic cardiomyopathy
- Cardiomyopathy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 5527 | 579 | 4785 |
Only index persons | 1818 | 218 | 1600 |
Unadjusted period prevalence (%) | |||
Whole population | 0.12 | 0.02 | 0.13 |
Only index persons | 0.05 | 0.01 | 0.06 |
Median age at first event (years) | |||
Whole population | 54.66 | 56.03 | 54.42 |
Only index persons | 58.18 | 59.42 | 58.01 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 147 | 13 | 134 |
Unadjusted period prevalence (%) | 0.06 | 0.01 | 0.07 |
Median age at first event (years) | 60.82 | 48.78 | 61.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOALC and mortality.
Females
No dataMales
Parameter | HR [95% CI] | p-value |
---|---|---|
I9_CARDMYOALC | 8.396 [6.95, 10.14] | < 0.001 |
Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 630 males with I9_CARDMYOALC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOALC.N-year risk | Females | Males |
---|---|---|
1 | No data | 1.353% |
5 | No data | 8.938% |
10 | No data | 20.736% |
15 | No data | 36.196% |
20 | No data | 53.948% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOALC – Alcoholic cardiomyopathy
GWS hits: -