cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2922 |
4. Check minimum number of eventsNone |
2922 |
5. Include endpointsNone |
2922 |
6. Filter based on genotype QC (FinnGen only) |
2844 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Cardiomyopathy, other and unspecified
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23467 | 8732 | 14423 |
| Only index persons | 17151 | 6748 | 10403 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.35 | 0.25 | 0.40 |
| Only index persons | 0.34 | 0.25 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 60.50 | 63.47 | 58.75 |
| Only index persons | 60.78 | 63.42 | 59.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2844 | 1151 | 1693 |
| Unadjusted period prevalence (%) | 0.69 | 0.45 | 0.85 |
| Median age at first event (years) | 59.99 | 60.54 | 59.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOOTH | 2.542 [2.24, 2.88] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.101 |
During the follow-up period (1.1.1998 — 31.12.2019), 1540 out of 5408 females with I9_CARDMYOOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOOTH | 2.934 [2.64, 3.26] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 3551 out of 8905 males with I9_CARDMYOOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.194% | 0.628% |
| 5 | 1.26% | 3.754% |
| 10 | 3.269% | 9.214% |
| 15 | 6.251% | 17.151% |
| 20 | 11.13% | 27.492% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOOTH – Cardiomyopathy, other and unspecified
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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