atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
57655 |
4. Check minimum number of eventsNone |
57655 |
5. Include endpoints |
57655 |
6. Filter based on genotype QC (FinnGen only) |
55853 |
Control definitions (FinnGen only)
Control exclude
FG_CVD
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I30-I52
Name in latin
Fibrillatio atriorum
Similar endpoints
↥List of similar endpoints to
Atrial fibrillation and flutter
based on the number of shared cases.
Similar with more cases:
- Cardiac arrhythmias
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 604062 | 286372 | 311083 |
| Only index persons | 464709 | 222369 | 242340 |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.44 | 8.20 | 8.69 |
| Only index persons | 8.74 | 8.17 | 9.25 |
| Median age at first event (years) | |||
| Whole population | 72.95 | 76.96 | 69.29 |
| Only index persons | 72.55 | 76.76 | 68.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55853 | 21088 | 34765 |
| Unadjusted period prevalence (%) | 13.99 | 8.28 | 17.46 |
| Median age at first event (years) | 69.64 | 71.41 | 68.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_AF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AF | 1.866 [1.72, 2.02] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 97565 out of 204865 females with I9_AF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AF | 2.006 [1.84, 2.19] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 88470 out of 215071 males with I9_AF died.
Mortality risk
Mortality risk for people of age
years, who have I9_AF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.216% |
| 5 | 0.759% | 1.558% |
| 10 | 1.863% | 3.741% |
| 15 | 3.4% | 6.97% |
| 20 | 5.644% | 11.395% |
Relationships between endpoints
↥Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 113
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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