No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
84938 |
6. Filter based on genotype QC (FinnGen only) |
82200 |
Control definitions (FinnGen only)
Control exclude
ILD_CVDMETABOCOMORB
Extra metadata
First used in FinnGen datafreeze
DF2
Cardiac arrhythmias
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 827871 | 414276 | 405262 |
| Only index persons | 658772 | 338150 | 320622 |
| Unadjusted period prevalence (%) | |||
| Whole population | 11.57 | 11.87 | 11.32 |
| Only index persons | 12.34 | 12.43 | 12.24 |
| Median age at first event (years) | |||
| Whole population | 69.21 | 71.95 | 66.39 |
| Only index persons | 67.96 | 70.51 | 65.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 82200 | 37668 | 44532 |
| Unadjusted period prevalence (%) | 18.90 | 14.79 | 22.36 |
| Median age at first event (years) | 65.43 | 64.31 | 66.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CARDIAC_ARRHYTM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CARDIAC_ARRHYTM | 1.727 [1.6, 1.87] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 105206 out of 299264 females with CARDIAC_ARRHYTM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CARDIAC_ARRHYTM | 1.713 [1.57, 1.86] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96774 out of 278557 males with CARDIAC_ARRHYTM died.
Mortality risk
Mortality risk for people of age
years, who have CARDIAC_ARRHYTM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.164% |
| 5 | 0.632% | 1.268% |
| 10 | 1.643% | 3.379% |
| 15 | 3.169% | 6.082% |
| 20 | 5.352% | 10.024% |
Relationships between endpoints
↥Index endpoint: CARDIAC_ARRHYTM – Cardiac arrhythmias
GWS hits: 82
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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