atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
57655 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
33857 |
4. Check minimum number of eventsNone |
33857 |
5. Include endpointsNone |
33857 |
6. Filter based on genotype QC (FinnGen only) |
32849 |
Control definitions (FinnGen only)
Control exclude
FG_CVD
Control conditions
not I9_AF
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Atrial fibrillation and flutter with reimbursement
based on the number of shared cases.
Similar with more cases:
- Atrial fibrillation and flutter
- Cardiac arrhythmias
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 271797 | 130007 | 140171 |
| Only index persons | 240475 | 116642 | 123833 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.81 | 3.72 | 3.92 |
| Only index persons | 4.51 | 4.29 | 4.73 |
| Median age at first event (years) | |||
| Whole population | 73.73 | 76.89 | 70.86 |
| Only index persons | 74.23 | 77.39 | 71.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 32849 | 13494 | 19355 |
| Unadjusted period prevalence (%) | 7.90 | 5.30 | 9.72 |
| Median age at first event (years) | 72.00 | 73.56 | 70.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_AF_REIMB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AF_REIMB | 1.304 [1.15, 1.48] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.111 |
During the follow-up period (1.1.1998 — 31.12.2019), 18758 out of 84578 females with I9_AF_REIMB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AF_REIMB | 1.414 [1.24, 1.62] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 18839 out of 88141 males with I9_AF_REIMB died.
Mortality risk
Mortality risk for people of age
years, who have I9_AF_REIMB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.204% |
| 5 | 0.684% | 1.415% |
| 10 | 1.734% | 3.575% |
| 15 | 3.216% | 6.863% |
| 20 | 5.826% | 11.12% |
Relationships between endpoints
↥Index endpoint: I9_AF_REIMB – Atrial fibrillation and flutter with reimbursement
GWS hits: 95
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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