No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
921 |
4. Check minimum number of eventsNone |
921 |
5. Include endpointsNone |
921 |
6. Filter based on genotype QC (FinnGen only) |
896 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dronedarone medication
based on the number of shared cases.
Similar with more cases:
- Atrial fibrillation and flutter
- Cardiac arrhythmias
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4159 | 1987 | 2166 |
| Only index persons | 4146 | 1983 | 2163 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.08 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 67.74 | 70.95 | 64.81 |
| Only index persons | 67.74 | 70.93 | 64.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 896 | 418 | 478 |
| Unadjusted period prevalence (%) | 0.20 | 0.16 | 0.24 |
| Median age at first event (years) | 67.33 | 69.89 | 65.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_E_DRONE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_E_DRONE | 0.927 [0.77, 1.11] | 0.406 |
| Birth year | 0.996 [0.99, 1.0] | 0.387 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 1798 females with I9_E_DRONE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_E_DRONE | 0.704 [0.59, 0.84] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 2019 males with I9_E_DRONE died.
Mortality risk
Mortality risk for people of age
years, who have I9_E_DRONE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.177% |
| 5 | 0.57% | 0.898% |
| 10 | 1.349% | 2.186% |
| 15 | 2.555% | 4.226% |
| 20 | 4.654% | 7.241% |
Relationships between endpoints
↥Index endpoint: I9_E_DRONE – Dronedarone medication
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data