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Other arrhythmias

DOID EFO Endpoint Browser PheWeb

I9_OTHARR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I49
  • Hospital discharge: ICD-9 — 427
  • Hospital discharge: ICD-8 — 42798
  • Hospital discharge: excluded ICD-9 — 4273
  • Hospital discharge: excluded ICD-8 — 42792
  • Cause of death: ICD-10 — I49
  • Cause of death: ICD-9 — 427
  • Cause of death: ICD-8 — 42798
  • Cause of death: excluded ICD-9 — 4273
  • Cause of death: excluded ICD-8 — 42792

2 out of 7 registries used, show all original rules.

36043

4. Check minimum number of events

None

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5. Include endpoints

None

36043

6. Filter based on genotype QC (FinnGen only)

34881

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Aliae arrhythmiae cordis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 294737 162579 129590
Only index persons 247058 141874 105184
Unadjusted period prevalence (%)
Whole population 4.18 4.66 3.62
Only index persons 4.70 5.22 4.02
Median age at first event (years)
Whole population 62.35 62.93 61.55
Only index persons 60.32 60.81 59.65

-FinnGen-

Key figures

All Female Male
Number of individuals 34881 19678 15203
Unadjusted period prevalence (%) 7.69 7.73 7.64
Median age at first event (years) 60.69 58.51 63.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_OTHARR and mortality.

Females

Parameter HR [95% CI] p-value
I9_OTHARR 1.13 [1.04, 1.23] 0.004
Birth year 0.991 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 22309 out of 117224 females with I9_OTHARR died.

Males

Parameter HR [95% CI] p-value
I9_OTHARR 1.009 [0.92, 1.1] 0.833
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 19413 out of 85809 males with I9_OTHARR died.

Mortality risk

Mortality risk for people of age

years, who have I9_OTHARR.

N-year risk Females Males
1 0.08% 0.175%
5 0.539% 1.178%
10 1.455% 2.97%
15 2.783% 5.866%
20 4.625% 9.997%

Relationships between endpoints

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Index endpoint: I9_OTHARR – Other arrhythmias

GWS hits: 13

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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