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Cardiac arrest

DOID EFO Endpoint Browser PheWeb

I9_CARDARR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I46
  • Hospital discharge: ICD-9 — 4275A|4112
  • Hospital discharge: ICD-8 — 4272
  • Cause of death: ICD-10 — I46
  • Cause of death: ICD-9 — 4275A|4112
  • Cause of death: ICD-8 — 4272

2 out of 7 registries used, show all original rules.

2813

4. Check minimum number of events

None

2813

5. Include endpoints

None

2813

6. Filter based on genotype QC (FinnGen only)

2722

Control definitions (FinnGen only)

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Asystolia

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36836 12963 23118
Only index persons 22152 7645 14507
Unadjusted period prevalence (%)
Whole population 0.55 0.37 0.65
Only index persons 0.46 0.28 0.55
Median age at first event (years)
Whole population 68.10 71.19 66.35
Only index persons 68.17 71.52 66.40

-FinnGen-

Key figures

All Female Male
Number of individuals 2722 737 1985
Unadjusted period prevalence (%) 0.81 0.29 1.00
Median age at first event (years) 67.47 63.90 68.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_CARDARR and mortality.

Females

Parameter HR [95% CI] p-value
I9_CARDARR 3.397 [2.88, 4.0] < 0.001
Birth year 0.991 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 1471 out of 3106 females with I9_CARDARR died.

Males

Parameter HR [95% CI] p-value
I9_CARDARR 3.423 [2.99, 3.92] < 0.001
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 3038 out of 6961 males with I9_CARDARR died.

Mortality risk

Mortality risk for people of age

years, who have I9_CARDARR.

N-year risk Females Males
1 0.272% 0.581%
5 1.763% 3.492%
10 4.451% 9.208%
15 8.304% 17.494%
20 13.989% 28.944%

Relationships between endpoints

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Index endpoint: I9_CARDARR – Cardiac arrest

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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