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Myocarditis

DOID EFO Endpoint Browser PheWeb

I9_MYOCARD

myocarditis: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus , Wegener's granulomatosis , giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and, rarely, a heart transplant may be needed if the heart muscle becomes weak. [ https://rarediseases.info.nih.gov/diseases/7137/myocarditis ]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I40, I41*
  • Hospital discharge: ICD-9 — 422
  • Hospital discharge: ICD-8 — 0742|422
  • Cause of death: ICD-10 — I40, I41*
  • Cause of death: ICD-9 — 422
  • Cause of death: ICD-8 — 0742|422

2 out of 7 registries used, show all original rules.

1911

4. Check minimum number of events

None

1911

5. Include endpoints

None

1911

6. Filter based on genotype QC (FinnGen only)

1847

Control definitions (FinnGen only)

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17932 5852 11924
Only index persons 14873 4677 10196
Unadjusted period prevalence (%)
Whole population 0.28 0.17 0.33
Only index persons 0.32 0.17 0.39
Median age at first event (years)
Whole population 39.71 50.66 34.06
Only index persons 36.53 48.02 31.26

-FinnGen-

Key figures

All Female Male
Number of individuals 1847 735 1112
Unadjusted period prevalence (%) 0.45 0.29 0.56
Median age at first event (years) 43.48 47.58 40.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_MYOCARD and mortality.

Females

Parameter HR [95% CI] p-value
I9_MYOCARD 1.922 [1.65, 2.24] < 0.001
Birth year 0.993 [0.99, 1.0] 0.121

During the follow-up period (1.1.1998 — 31.12.2019), 807 out of 3243 females with I9_MYOCARD died.

Males

Parameter HR [95% CI] p-value
I9_MYOCARD 1.902 [1.66, 2.18] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1142 out of 6956 males with I9_MYOCARD died.

Mortality risk

Mortality risk for people of age

years, who have I9_MYOCARD.

N-year risk Females Males
1 0.158% 0.292%
5 0.99% 1.77%
10 2.631% 4.585%
15 5.079% 8.551%
20 8.959% 14.163%

Relationships between endpoints

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Index endpoint: I9_MYOCARD – Myocarditis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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