No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
12786 |
4. Check minimum number of eventsNone |
12786 |
5. Include endpoints |
12786 |
6. Filter based on genotype QC (FinnGen only) |
12371 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Conduction disorders
based on the number of shared cases.
Similar with more cases:
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 103368 | 46546 | 55910 |
| Only index persons | 85292 | 38808 | 46484 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.45 | 1.33 | 1.56 |
| Only index persons | 1.62 | 1.43 | 1.77 |
| Median age at first event (years) | |||
| Whole population | 72.64 | 73.84 | 71.61 |
| Only index persons | 71.52 | 72.41 | 70.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12371 | 4960 | 7411 |
| Unadjusted period prevalence (%) | 3.01 | 1.95 | 3.72 |
| Median age at first event (years) | 69.22 | 66.19 | 71.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CONDUCTIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CONDUCTIO | 1.515 [1.38, 1.67] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.502 |
During the follow-up period (1.1.1998 — 31.12.2019), 12811 out of 34776 females with I9_CONDUCTIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CONDUCTIO | 1.575 [1.41, 1.76] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 15576 out of 41184 males with I9_CONDUCTIO died.
Mortality risk
Mortality risk for people of age
years, who have I9_CONDUCTIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.174% | 0.232% |
| 5 | 0.967% | 1.584% |
| 10 | 2.241% | 4.067% |
| 15 | 4.535% | 7.723% |
| 20 | 7.731% | 12.925% |
Relationships between endpoints
↥Index endpoint: I9_CONDUCTIO – Conduction disorders
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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