No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2492 |
4. Check minimum number of eventsNone |
2492 |
5. Include endpointsNone |
2492 |
6. Filter based on genotype QC (FinnGen only) |
2419 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Left bundle-branch block
based on the number of shared cases.
Similar with more cases:
- Conduction disorders
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17107 | 8747 | 8259 |
| Only index persons | 14924 | 7794 | 7130 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.25 | 0.23 |
| Only index persons | 0.28 | 0.29 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 69.91 | 70.38 | 69.35 |
| Only index persons | 69.06 | 69.43 | 68.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2419 | 1220 | 1199 |
| Unadjusted period prevalence (%) | 0.54 | 0.48 | 0.60 |
| Median age at first event (years) | 67.80 | 66.19 | 69.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_LBBB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_LBBB | 1.485 [1.31, 1.69] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 1404 out of 6319 females with I9_LBBB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_LBBB | 1.602 [1.39, 1.85] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1722 out of 5910 males with I9_LBBB died.
Mortality risk
Mortality risk for people of age
years, who have I9_LBBB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.242% |
| 5 | 0.711% | 1.661% |
| 10 | 1.908% | 4.146% |
| 15 | 3.579% | 8.024% |
| 20 | 6.132% | 13.259% |
Relationships between endpoints
↥Index endpoint: I9_LBBB – Left bundle-branch block
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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