No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1222 |
4. Check minimum number of eventsNone |
1222 |
5. Include endpointsNone |
1222 |
6. Filter based on genotype QC (FinnGen only) |
1186 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Right bundle-branch block
based on the number of shared cases.
Similar with more cases:
- Conduction disorders
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9484 | 3939 | 5460 |
| Only index persons | 7783 | 3301 | 4482 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.11 | 0.15 |
| Only index persons | 0.15 | 0.12 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 68.95 | 70.74 | 67.60 |
| Only index persons | 67.26 | 68.85 | 66.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1186 | 461 | 725 |
| Unadjusted period prevalence (%) | 0.29 | 0.18 | 0.36 |
| Median age at first event (years) | 66.32 | 63.42 | 68.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_RBBB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RBBB | 1.7 [1.49, 1.94] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.141 |
During the follow-up period (1.1.1998 — 31.12.2019), 1067 out of 3047 females with I9_RBBB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RBBB | 1.463 [1.27, 1.69] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1193 out of 3879 males with I9_RBBB died.
Mortality risk
Mortality risk for people of age
years, who have I9_RBBB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.279% |
| 5 | 0.97% | 1.671% |
| 10 | 2.426% | 4.319% |
| 15 | 4.593% | 8.042% |
| 20 | 7.591% | 13.486% |
Relationships between endpoints
↥Index endpoint: I9_RBBB – Right bundle-branch block
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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