No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7173 |
4. Check minimum number of eventsNone |
7173 |
5. Include endpointsNone |
7173 |
6. Filter based on genotype QC (FinnGen only) |
6935 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
AV-block
based on the number of shared cases.
Similar with more cases:
- Conduction disorders
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 58869 | 24350 | 33925 |
| Only index persons | 47420 | 19601 | 27819 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.84 | 0.70 | 0.95 |
| Only index persons | 0.92 | 0.72 | 1.06 |
| Median age at first event (years) | |||
| Whole population | 75.90 | 77.69 | 74.64 |
| Only index persons | 75.56 | 77.29 | 74.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6935 | 2234 | 4701 |
| Unadjusted period prevalence (%) | 1.88 | 0.88 | 2.36 |
| Median age at first event (years) | 73.07 | 71.92 | 73.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_AVBLOCK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AVBLOCK | 1.452 [1.32, 1.6] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.367 |
During the follow-up period (1.1.1998 — 31.12.2019), 7774 out of 17757 females with I9_AVBLOCK died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_AVBLOCK | 1.52 [1.35, 1.71] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 11011 out of 25102 males with I9_AVBLOCK died.
Mortality risk
Mortality risk for people of age
years, who have I9_AVBLOCK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.156% | 0.261% |
| 5 | 0.804% | 1.655% |
| 10 | 2.125% | 4.103% |
| 15 | 3.958% | 7.949% |
| 20 | 7.145% | 13.415% |
Relationships between endpoints
↥Index endpoint: I9_AVBLOCK – AV-block
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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