heart valve disease: A disease involving the cardial valve.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
26316 |
6. Filter based on genotype QC (FinnGen only) |
25372 |
Control definitions (FinnGen only)
Control exclude
I9_OTHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Valvular heart disease excluding rheumatic fever
based on the number of shared cases.
Similar with more cases:
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 217192 | 107750 | 107449 |
| Only index persons | 176491 | 88289 | 88202 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.04 | 3.09 | 3.00 |
| Only index persons | 3.31 | 3.25 | 3.37 |
| Median age at first event (years) | |||
| Whole population | 71.71 | 74.29 | 69.13 |
| Only index persons | 71.19 | 73.61 | 68.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 25372 | 10765 | 14607 |
| Unadjusted period prevalence (%) | 6.02 | 4.23 | 7.34 |
| Median age at first event (years) | 68.97 | 69.24 | 68.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_VHD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VHD | 1.782 [1.63, 1.94] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 31009 out of 80488 females with I9_VHD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_VHD | 1.65 [1.5, 1.81] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 28964 out of 79155 males with I9_VHD died.
Mortality risk
Mortality risk for people of age
years, who have I9_VHD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.282% |
| 5 | 0.69% | 1.671% |
| 10 | 1.911% | 4.544% |
| 15 | 3.775% | 8.684% |
| 20 | 6.546% | 14.849% |
Relationships between endpoints
↥Index endpoint: I9_VHD – Valvular heart disease excluding rheumatic fever
GWS hits: 12
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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