No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
11460 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
11460 |
6. Filter based on genotype QC (FinnGen only) |
11047 |
Control definitions (FinnGen only)
Control conditions
not I9_CAVS_OPERATIONS1
or I9_CAVS_OPERATIONS2
or I9_CAVS_OPERATIONS2
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Calcific aortic valvular stenosis, operated
based on the number of shared cases.
Similar with more cases:
- Calcific aortic valvular stenosis
- Valvular heart disease excluding rheumatic fever
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 98668 | 48773 | 48987 |
| Only index persons | 79459 | 39185 | 40274 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.38 | 1.40 | 1.37 |
| Only index persons | 1.49 | 1.44 | 1.54 |
| Median age at first event (years) | |||
| Whole population | 75.89 | 78.69 | 73.13 |
| Only index persons | 75.73 | 78.58 | 72.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11047 | 4141 | 6906 |
| Unadjusted period prevalence (%) | 2.78 | 1.63 | 3.47 |
| Median age at first event (years) | 72.83 | 74.33 | 71.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CAVS_OPERATED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CAVS_OPERATED | 1.9 [1.73, 2.09] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.329 |
During the follow-up period (1.1.1998 — 31.12.2019), 18397 out of 36467 females with I9_CAVS_OPERATED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CAVS_OPERATED | 1.714 [1.54, 1.91] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 16039 out of 36231 males with I9_CAVS_OPERATED died.
Mortality risk
Mortality risk for people of age
years, who have I9_CAVS_OPERATED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.136% | 0.271% |
| 5 | 1.089% | 1.731% |
| 10 | 2.888% | 4.109% |
| 15 | 5.133% | 7.608% |
| 20 | 8.919% | 12.528% |
Relationships between endpoints
↥Index endpoint: I9_CAVS_OPERATED – Calcific aortic valvular stenosis, operated
GWS hits: 23
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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