heart valve disease: A disease involving the cardial valve.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
26137 |
4. Check minimum number of eventsNone |
26137 |
5. Include endpointsNone |
26137 |
6. Filter based on genotype QC (FinnGen only) |
25200 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Non-rheumatic valve diseases based on the number of shared cases.
Similar with more cases:
- Valvular heart disease excluding rheumatic fever
- Other heart diseases
- Other heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 215676 | 107164 | 106544 |
Only index persons | 175595 | 87966 | 87629 |
Unadjusted period prevalence (%) | |||
Whole population | 3.01 | 3.07 | 2.98 |
Only index persons | 3.29 | 3.23 | 3.35 |
Median age at first event (years) | |||
Whole population | 71.82 | 74.38 | 69.26 |
Only index persons | 71.28 | 73.70 | 68.86 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 25200 | 10703 | 14497 |
Unadjusted period prevalence (%) | 5.97 | 4.20 | 7.28 |
Median age at first event (years) | 69.04 | 69.30 | 68.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_NONRHEVALV and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
I9_NONRHEVALV | 1.736 [1.59, 1.89] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 31028 out of 80329 females with I9_NONRHEVALV died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
I9_NONRHEVALV | 1.699 [1.55, 1.87] | < 0.001 |
Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 28903 out of 78811 males with I9_NONRHEVALV died.
Mortality risk
Mortality risk for people of age
years, who have I9_NONRHEVALV.N-year risk | Females | Males |
---|---|---|
1 | 0.163% | 0.268% |
5 | 0.874% | 1.582% |
10 | 2.138% | 3.94% |
15 | 4.021% | 7.365% |
20 | 6.991% | 12.656% |
Relationships between endpoints
↥Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases
GWS hits: 10