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Pericarditis

DOID EFO Endpoint Browser PheWeb

I9_PERICARD

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I30, I32*
  • Hospital discharge: ICD-9 — 420
  • Hospital discharge: ICD-8 — 420
  • Cause of death: ICD-10 — I30, I32*
  • Cause of death: ICD-9 — 420
  • Cause of death: ICD-8 — 420

2 out of 7 registries used, show all original rules.

1250

4. Check minimum number of events

None

1250

5. Include endpoints

None

1250

6. Filter based on genotype QC (FinnGen only)

1203

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11148 3965 7055
Only index persons 8429 2937 5492
Unadjusted period prevalence (%)
Whole population 0.17 0.11 0.20
Only index persons 0.17 0.11 0.21
Median age at first event (years)
Whole population 52.56 60.45 47.91
Only index persons 47.96 57.21 43.01

-FinnGen-

Key figures

All Female Male
Number of individuals 1203 458 745
Unadjusted period prevalence (%) 0.30 0.18 0.37
Median age at first event (years) 53.69 54.14 53.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_PERICARD and mortality.

Females

Parameter HR [95% CI] p-value
I9_PERICARD 2.435 [2.09, 2.83] < 0.001
Birth year 0.992 [0.98, 1.0] 0.073

During the follow-up period (1.1.1998 — 31.12.2019), 816 out of 2298 females with I9_PERICARD died.

Males

Parameter HR [95% CI] p-value
I9_PERICARD 1.709 [1.5, 1.94] < 0.001
Birth year 0.991 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 844 out of 3737 males with I9_PERICARD died.

Mortality risk

Mortality risk for people of age

years, who have I9_PERICARD.

N-year risk Females Males
1 0.234% 0.323%
5 1.469% 2.054%
10 3.199% 5.322%
15 6.159% 10.534%
20 10.517% 17.41%

Relationships between endpoints

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Index endpoint: I9_PERICARD – Pericarditis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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