kidney disease: A disease involving the kidney.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
7062 |
6. Filter based on genotype QC (FinnGen only) |
6764 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 55801 | 22746 | 32301 |
Only index persons | 42161 | 17429 | 24732 |
Unadjusted period prevalence (%) | |||
Whole population | 0.80 | 0.65 | 0.90 |
Only index persons | 0.82 | 0.64 | 0.94 |
Median age at first event (years) | |||
Whole population | 54.70 | 54.28 | 54.85 |
Only index persons | 50.65 | 48.56 | 52.11 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 6764 | 2738 | 4026 |
Unadjusted period prevalence (%) | 1.64 | 1.08 | 2.02 |
Median age at first event (years) | 51.66 | 45.06 | 56.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_GLOMERULAR and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
N14_GLOMERULAR | 4.103 [3.72, 4.52] | < 0.001 |
Birth year | 0.994 [0.99, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 5375 out of 14487 females with N14_GLOMERULAR died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
N14_GLOMERULAR | 3.591 [3.24, 3.99] | < 0.001 |
Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 8430 out of 19789 males with N14_GLOMERULAR died.
Mortality risk
Mortality risk for people of age
years, who have N14_GLOMERULAR.N-year risk | Females | Males |
---|---|---|
1 | 0.433% | 0.542% |
5 | 2.173% | 3.722% |
10 | 5.372% | 9.104% |
15 | 10.614% | 16.758% |
20 | 18.013% | 26.663% |
Relationships between endpoints
↥Index endpoint: N14_GLOMERULAR – Glomerular diseases
GWS hits: 1