Glomerular diseases

N14_GLOMERULAR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

7062

6. Filter based on genotype QC (FinnGen only)

6764

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 55801 22746 32301
Only index persons 42161 17429 24732
Unadjusted period prevalence (%)
Whole population 0.80 0.65 0.90
Only index persons 0.82 0.64 0.94
Median age at first event (years)
Whole population 54.70 54.28 54.85
Only index persons 50.65 48.56 52.11

-FinnGen-

Key figures

All Female Male
Number of individuals 6764 2738 4026
Unadjusted period prevalence (%) 1.64 1.08 2.02
Median age at first event (years) 51.66 45.06 56.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_GLOMERULAR and mortality.

Females

Parameter HR [95% CI] p-value
N14_GLOMERULAR 4.103 [3.72, 4.52] < 0.001
Birth year 0.994 [0.99, 1.0] 0.118

During the follow-up period (1.1.1998 — 31.12.2019), 5375 out of 14487 females with N14_GLOMERULAR died.

Males

Parameter HR [95% CI] p-value
N14_GLOMERULAR 3.591 [3.24, 3.99] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 8430 out of 19789 males with N14_GLOMERULAR died.

Mortality risk

Mortality risk for people of age

years, who have N14_GLOMERULAR.

N-year risk Females Males
1 0.433% 0.542%
5 2.173% 3.722%
10 5.372% 9.104%
15 10.614% 16.758%
20 18.013% 26.663%

Relationships between endpoints

Index endpoint: N14_GLOMERULAR – Glomerular diseases

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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