No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
763 |
4. Check minimum number of eventsNone |
763 |
5. Include endpointsNone |
763 |
6. Filter based on genotype QC (FinnGen only) |
726 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
IgA nephropathy (IgA glomerulonephritis)
based on the number of shared cases.
Similar with more cases:
- Other and unspecified disorders involving the immune mechanism, not elsewhere classified
- Other disorders involving the immune mechanism, not elsewhere classified
- Glomerular disorders in diseases classified elsewhere
- Glomerular diseases
- Certain disorders involving the immune mechanism
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4061 | 1386 | 2634 |
| Only index persons | 3760 | 1331 | 2429 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.04 | 0.07 |
| Only index persons | 0.08 | 0.05 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 46.98 | 42.39 | 49.52 |
| Only index persons | 46.14 | 42.13 | 48.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 726 | 265 | 461 |
| Unadjusted period prevalence (%) | 0.19 | 0.10 | 0.23 |
| Median age at first event (years) | 48.18 | 42.24 | 51.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_IGA_NEPHROPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_IGA_NEPHROPATHY | 2.567 [2.14, 3.08] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.191 |
During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1288 females with N14_IGA_NEPHROPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_IGA_NEPHROPATHY | 2.249 [1.99, 2.54] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 541 out of 2443 males with N14_IGA_NEPHROPATHY died.
Mortality risk
Mortality risk for people of age
years, who have N14_IGA_NEPHROPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.264% | 0.378% |
| 5 | 1.454% | 2.341% |
| 10 | 3.623% | 6.074% |
| 15 | 7.022% | 11.139% |
| 20 | 12.642% | 18.605% |
Relationships between endpoints
↥Index endpoint: N14_IGA_NEPHROPATHY – IgA nephropathy (IgA glomerulonephritis)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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