nephritis: Inflammation of renal tissue. [ NCIT:P378 ]
Glomerular disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
N14_GLOMEINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4224 |
4. Check minimum number of eventsNone |
4224 |
5. Include endpointsNone |
4224 |
6. Filter based on genotype QC (FinnGen only) |
4046 |
Control definitions (FinnGen only)
Control exclude
N14_GLOMERULAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Glomerular disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27234 | 10428 | 16506 |
| Only index persons | 21831 | 8230 | 13601 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.30 | 0.46 |
| Only index persons | 0.44 | 0.30 | 0.52 |
| Median age at first event (years) | |||
| Whole population | 61.78 | 61.75 | 61.74 |
| Only index persons | 60.29 | 58.86 | 61.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4046 | 1515 | 2531 |
| Unadjusted period prevalence (%) | 1.02 | 0.60 | 1.27 |
| Median age at first event (years) | 58.01 | 52.77 | 61.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_GLOMEINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_GLOMEINOTH | 5.805 [5.18, 6.51] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.979 |
During the follow-up period (1.1.1998 — 31.12.2019), 3761 out of 8614 females with N14_GLOMEINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_GLOMEINOTH | 4.34 [3.9, 4.83] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 6508 out of 13997 males with N14_GLOMEINOTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_GLOMEINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.512% | 0.785% |
| 5 | 3.903% | 4.753% |
| 10 | 8.956% | 11.345% |
| 15 | 16.317% | 20.563% |
| 20 | 29.259% | 32.099% |
Relationships between endpoints
↥Index endpoint: N14_GLOMEINOTH – Glomerular disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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