No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
118 |
4. Check minimum number of eventsNone |
118 |
5. Include endpointsNone |
118 |
6. Filter based on genotype QC (FinnGen only) |
115 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Henoch-Schönlein purpura nephritis (HSPN)
based on the number of shared cases.
Similar with more cases:
- Allergic purpura
- Glomerular disorders in diseases classified elsewhere
- Purpura and other haemorrhagic conditions
- Glomerular diseases
- Coagulation defects, purpura and other haemorrhagic conditions
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1118 | 469 | 646 |
| Only index persons | 1031 | 442 | 589 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 22.53 | 20.27 | 24.01 |
| Only index persons | 23.01 | 21.65 | 24.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 115 | 61 | 54 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 43.64 | 33.72 | 54.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_HENOCHSCHONLEIN_NEPHRITIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_HENOCHSCHONLEIN_NEPHRITIS | 2.718 [1.97, 3.75] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 588 males with N14_HENOCHSCHONLEIN_NEPHRITIS died.
Mortality risk
Mortality risk for people of age
years, who have N14_HENOCHSCHONLEIN_NEPHRITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.508% |
| 5 | No data | 2.64% |
| 10 | No data | 6.883% |
| 15 | No data | 12.352% |
| 20 | No data | 20.208% |
Relationships between endpoints
↥Index endpoint: N14_HENOCHSCHONLEIN_NEPHRITIS – Henoch-Schönlein purpura nephritis (HSPN)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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