No definition available.
Coagulation defects, purpura and other haemorrhagic conditions
EFO MESH Endpoint Browser PheWeb
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
7505 |
6. Filter based on genotype QC (FinnGen only) |
7202 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Coagulation defects, purpura and other haemorrhagic conditions
based on the number of shared cases.
Similar with more cases:
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 67221 | 35241 | 31460 |
| Only index persons | 56925 | 30781 | 26144 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.94 | 1.01 | 0.88 |
| Only index persons | 1.07 | 1.13 | 1.00 |
| Median age at first event (years) | |||
| Whole population | 51.21 | 48.10 | 54.52 |
| Only index persons | 48.68 | 44.82 | 53.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7202 | 4113 | 3089 |
| Unadjusted period prevalence (%) | 1.59 | 1.62 | 1.55 |
| Median age at first event (years) | 52.54 | 45.58 | 61.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_COAGDEF_PURPUR_HAEMORRHAGIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF_PURPUR_HAEMORRHAGIC | 2.476 [2.24, 2.74] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.297 |
During the follow-up period (1.1.1998 — 31.12.2019), 5469 out of 25138 females with D3_COAGDEF_PURPUR_HAEMORRHAGIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF_PURPUR_HAEMORRHAGIC | 2.664 [2.39, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 6555 out of 21267 males with D3_COAGDEF_PURPUR_HAEMORRHAGIC died.
Mortality risk
Mortality risk for people of age
years, who have D3_COAGDEF_PURPUR_HAEMORRHAGIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.194% | 0.486% |
| 5 | 1.425% | 2.986% |
| 10 | 3.355% | 7.221% |
| 15 | 6.616% | 13.413% |
| 20 | 11.192% | 21.612% |
Relationships between endpoints
↥Index endpoint: D3_COAGDEF_PURPUR_HAEMORRHAGIC – Coagulation defects, purpura and other haemorrhagic conditions
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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