No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2400 |
4. Check minimum number of eventsNone |
2400 |
5. Include endpointsNone |
2400 |
6. Filter based on genotype QC (FinnGen only) |
2295 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Thrombocytopenia NAS
Similar endpoints
↥List of similar endpoints to
Thrombocytopenia, unspecified
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20979 | 9790 | 11000 |
| Only index persons | 17647 | 8393 | 9254 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.28 | 0.31 |
| Only index persons | 0.33 | 0.31 | 0.35 |
| Median age at first event (years) | |||
| Whole population | 60.24 | 59.26 | 61.06 |
| Only index persons | 59.45 | 57.70 | 61.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2295 | 1083 | 1212 |
| Unadjusted period prevalence (%) | 0.52 | 0.43 | 0.61 |
| Median age at first event (years) | 60.56 | 55.01 | 65.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_THROMBOCYTOPENIANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_THROMBOCYTOPENIANAS | 2.959 [2.61, 3.36] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.239 |
During the follow-up period (1.1.1998 — 31.12.2019), 2428 out of 7148 females with D3_THROMBOCYTOPENIANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_THROMBOCYTOPENIANAS | 3.095 [2.72, 3.52] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.474 |
During the follow-up period (1.1.1998 — 31.12.2019), 3444 out of 8372 males with D3_THROMBOCYTOPENIANAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_THROMBOCYTOPENIANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.242% | 0.6% |
| 5 | 1.655% | 4.353% |
| 10 | 4.4% | 10.977% |
| 15 | 8.294% | 19.863% |
| 20 | 14.628% | 32.578% |
Relationships between endpoints
↥Index endpoint: D3_THROMBOCYTOPENIANAS – Thrombocytopenia, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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