No definition available.
Purpura and other haemorrhagic conditions
DOID EFO Endpoint Browser PheWeb
D3_PURPURA_AND3_OTHER_HAEMORRHAGIC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4452 |
4. Check minimum number of eventsNone |
4452 |
5. Include endpoints |
4997 |
6. Filter based on genotype QC (FinnGen only) |
4789 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D65-D69
Name in latin
Purpura et alii status haemorrhagici
Similar endpoints
↥List of similar endpoints to
Purpura and other haemorrhagic conditions
based on the number of shared cases.
Similar with more cases:
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 46359 | 22834 | 23162 |
| Only index persons | 38984 | 19590 | 19394 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.65 | 0.65 | 0.65 |
| Only index persons | 0.73 | 0.72 | 0.74 |
| Median age at first event (years) | |||
| Whole population | 53.17 | 52.56 | 53.62 |
| Only index persons | 51.14 | 49.94 | 52.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4789 | 2531 | 2258 |
| Unadjusted period prevalence (%) | 1.06 | 0.99 | 1.13 |
| Median age at first event (years) | 55.39 | 49.18 | 62.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_PURPURA_AND3_OTHER_HAEMORRHAGIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_PURPURA_AND3_OTHER_HAEMORRHAGIC | 2.514 [2.28, 2.78] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.05 |
During the follow-up period (1.1.1998 — 31.12.2019), 4584 out of 16026 females with D3_PURPURA_AND3_OTHER_HAEMORRHAGIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_PURPURA_AND3_OTHER_HAEMORRHAGIC | 2.862 [2.55, 3.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 5559 out of 16338 males with D3_PURPURA_AND3_OTHER_HAEMORRHAGIC died.
Mortality risk
Mortality risk for people of age
years, who have D3_PURPURA_AND3_OTHER_HAEMORRHAGIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.2% | 0.642% |
| 5 | 1.373% | 3.25% |
| 10 | 3.513% | 7.796% |
| 15 | 6.314% | 13.524% |
| 20 | 10.521% | 22.98% |
Relationships between endpoints
↥Index endpoint: D3_PURPURA_AND3_OTHER_HAEMORRHAGIC – Purpura and other haemorrhagic conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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