No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
278 |
4. Check minimum number of eventsNone |
278 |
5. Include endpointsNone |
278 |
6. Filter based on genotype QC (FinnGen only) |
272 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Purpura non thrombocytopenica
Similar endpoints
↥List of similar endpoints to
Other nonthrombocytopenic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2281 | 1241 | 1022 |
| Only index persons | 1995 | 1125 | 870 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 61.62 | 63.49 | 59.23 |
| Only index persons | 59.44 | 61.58 | 56.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 272 | 161 | 111 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 59.21 | 56.92 | 62.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHNONTHROMBOCYTOPENPURPURA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHNONTHROMBOCYTOPENPURPURA | 1.597 [1.33, 1.92] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.101 |
During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 1034 females with D3_OTHNONTHROMBOCYTOPENPURPURA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHNONTHROMBOCYTOPENPURPURA | 2.141 [1.7, 2.7] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 268 out of 813 males with D3_OTHNONTHROMBOCYTOPENPURPURA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHNONTHROMBOCYTOPENPURPURA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.389% |
| 5 | 0.854% | 2.614% |
| 10 | 2.273% | 6.654% |
| 15 | 4.128% | 12.93% |
| 20 | 7.356% | 21.529% |
Relationships between endpoints
↥Index endpoint: D3_OTHNONTHROMBOCYTOPENPURPURA – Other nonthrombocytopenic purpura
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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