≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other primary thrombocytopenia

DOID Endpoint Browser PheWeb

D3_OTHPRIMTHROMBOCYTOPENIA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D69.4
  • Hospital discharge: ICD-9 — 2873
  • Hospital discharge: excluded ICD-9 — 2873A
  • Cause of death: ICD-10 — D69.4
  • Cause of death: ICD-9 — 2873
  • Cause of death: excluded ICD-9 — 2873A

2 out of 7 registries used, show all original rules.

125

4. Check minimum number of events

None

125

5. Include endpoints

None

125

6. Filter based on genotype QC (FinnGen only)

116

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Alia thrombocytopenia primaria

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1180 637 530
Only index persons 901 512 389
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 52.63 48.40 57.23
Only index persons 45.98 40.32 53.43

-FinnGen-

Key figures

All Female Male
Number of individuals 116 72 44
Unadjusted period prevalence (%) 0.03 0.03 0.02
Median age at first event (years) 46.60 38.74 59.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint D3_OTHPRIMTHROMBOCYTOPENIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_OTHPRIMTHROMBOCYTOPENIA 2.493 [1.72, 3.61] < 0.001
Birth year 0.994 [0.99, 1.0] 0.153

During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 392 females with D3_OTHPRIMTHROMBOCYTOPENIA died.

Males

Parameter HR [95% CI] p-value
D3_OTHPRIMTHROMBOCYTOPENIA 2.598 [1.6, 4.21] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 333 males with D3_OTHPRIMTHROMBOCYTOPENIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHPRIMTHROMBOCYTOPENIA.

N-year risk Females Males
1 0.238% 0.479%
5 1.336% 2.855%
10 3.226% 6.937%
15 6.591% 13.331%
20 11.845% 21.59%

Relationships between endpoints

↥

Index endpoint: D3_OTHPRIMTHROMBOCYTOPENIA – Other primary thrombocytopenia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data