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Other and unspecified haemorrhagic conditions

DOID EFO Endpoint Browser PheWeb

D3_HAEMORRHAGICNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D69.9
  • Hospital discharge: ICD-9 — 287[8-9]
  • Hospital discharge: ICD-8 — 2879
  • Hospital discharge: excluded ICD-8 — 28790
  • Cause of death: ICD-10 — D69.9
  • Cause of death: ICD-9 — 287[8-9]
  • Cause of death: ICD-8 — 2879
  • Cause of death: excluded ICD-8 — 28790

2 out of 7 registries used, show all original rules.

522

4. Check minimum number of events

None

522

5. Include endpoints

None

522

6. Filter based on genotype QC (FinnGen only)

494

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 D69
Name in latin Status haemorrhagicus non specificatus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4553 2524 1979
Only index persons 3723 2126 1597
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.06
Only index persons 0.07 0.08 0.06
Median age at first event (years)
Whole population 55.34 53.94 56.82
Only index persons 52.24 50.26 54.86

-FinnGen-

Key figures

All Female Male
Number of individuals 494 296 198
Unadjusted period prevalence (%) 0.11 0.12 0.10
Median age at first event (years) 53.35 48.23 61.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_HAEMORRHAGICNAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_HAEMORRHAGICNAS 2.577 [2.13, 3.11] < 0.001
Birth year 0.996 [0.99, 1.0] 0.377

During the follow-up period (1.1.1998 — 31.12.2019), 542 out of 1833 females with D3_HAEMORRHAGICNAS died.

Males

Parameter HR [95% CI] p-value
D3_HAEMORRHAGICNAS 2.773 [2.18, 3.53] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 549 out of 1402 males with D3_HAEMORRHAGICNAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMORRHAGICNAS.

N-year risk Females Males
1 0.304% 0.488%
5 1.55% 3.02%
10 3.838% 7.322%
15 6.969% 14.394%
20 12.299% 23.449%

Relationships between endpoints

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Index endpoint: D3_HAEMORRHAGICNAS – Other and unspecified haemorrhagic conditions

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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