autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1001 |
4. Check minimum number of eventsNone |
1001 |
5. Include endpointsNone |
1001 |
6. Filter based on genotype QC (FinnGen only) |
968 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Purpura idiopathica thrombocytopenica
Similar endpoints
↥List of similar endpoints to
Idiopathic thrombocytopenic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9562 | 4823 | 4657 |
| Only index persons | 8094 | 4155 | 3939 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.13 |
| Only index persons | 0.15 | 0.15 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 50.61 | 48.79 | 52.21 |
| Only index persons | 47.50 | 45.05 | 50.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 968 | 511 | 457 |
| Unadjusted period prevalence (%) | 0.21 | 0.20 | 0.23 |
| Median age at first event (years) | 50.03 | 40.94 | 60.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ITP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.136 [1.84, 2.48] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 792 out of 3356 females with D3_ITP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.157 [1.83, 2.54] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 954 out of 3358 males with D3_ITP died.
Mortality risk
Mortality risk for people of age
years, who have D3_ITP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.403% |
| 5 | 0.979% | 2.627% |
| 10 | 2.315% | 6.513% |
| 15 | 4.587% | 11.842% |
| 20 | 8.251% | 20.907% |
Relationships between endpoints
↥Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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