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Secondary thrombocytopenia

DOID EFO Endpoint Browser PheWeb

D3_SCNDTHROMBOCYTOPENIA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D69.5#
  • Hospital discharge: ICD-9 — 2874
  • Hospital discharge: ICD-8 — 28711
  • Cause of death: ICD-10 — D69.5#
  • Cause of death: ICD-9 — 2874
  • Cause of death: ICD-8 — 28711

2 out of 7 registries used, show all original rules.

387

4. Check minimum number of events

None

387

5. Include endpoints

None

387

6. Filter based on genotype QC (FinnGen only)

372

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Thrombocytopenia secundaria

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3098 1537 1524
Only index persons 2347 1177 1170
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 61.19 61.53 60.87
Only index persons 60.76 60.97 60.54

-FinnGen-

Key figures

All Female Male
Number of individuals 372 190 182
Unadjusted period prevalence (%) 0.08 0.07 0.09
Median age at first event (years) 60.82 58.87 62.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_SCNDTHROMBOCYTOPENIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_SCNDTHROMBOCYTOPENIA 6.962 [5.14, 9.44] < 0.001
Birth year 0.999 [0.99, 1.01] 0.753

During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 941 females with D3_SCNDTHROMBOCYTOPENIA died.

Males

Parameter HR [95% CI] p-value
D3_SCNDTHROMBOCYTOPENIA 6.625 [4.83, 9.08] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 505 out of 932 males with D3_SCNDTHROMBOCYTOPENIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_SCNDTHROMBOCYTOPENIA.

N-year risk Females Males
1 0.688% 0.814%
5 4.254% 6.786%
10 9.942% 17.034%
15 19.081% 30.032%
20 33.067% 46.714%

Relationships between endpoints

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Index endpoint: D3_SCNDTHROMBOCYTOPENIA – Secondary thrombocytopenia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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