Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1071 |
4. Check minimum number of eventsNone |
1071 |
5. Include endpointsNone |
1071 |
6. Filter based on genotype QC (FinnGen only) |
1031 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Purpura allergica
Similar endpoints
↥List of similar endpoints to
Allergic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11658 | 5675 | 5938 |
| Only index persons | 10225 | 5070 | 5155 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | 0.17 |
| Only index persons | 0.19 | 0.19 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 19.15 | 23.45 | 14.73 |
| Only index persons | 18.96 | 23.33 | 14.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1031 | 603 | 428 |
| Unadjusted period prevalence (%) | 0.23 | 0.24 | 0.21 |
| Median age at first event (years) | 39.18 | 33.72 | 46.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ALLERGPURPURA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ALLERGPURPURA | 1.684 [1.48, 1.91] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.726 |
During the follow-up period (1.1.1998 — 31.12.2019), 714 out of 4075 females with D3_ALLERGPURPURA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ALLERGPURPURA | 2.061 [1.77, 2.4] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 715 out of 3988 males with D3_ALLERGPURPURA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ALLERGPURPURA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.383% |
| 5 | 1.231% | 2.411% |
| 10 | 2.985% | 5.958% |
| 15 | 5.514% | 11.65% |
| 20 | 9.794% | 19.138% |
Relationships between endpoints
↥Index endpoint: D3_ALLERGPURPURA – Allergic purpura
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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