blood coagulation disease: A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1627 |
4. Check minimum number of eventsNone |
1627 |
5. Include endpointsNone |
1627 |
6. Filter based on genotype QC (FinnGen only) |
1569 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified coagulation defects
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11374 | 7399 | 3902 |
| Only index persons | 10454 | 6997 | 3457 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.11 |
| Only index persons | 0.22 | 0.26 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 41.80 | 37.06 | 50.90 |
| Only index persons | 41.92 | 37.10 | 51.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1569 | 1097 | 472 |
| Unadjusted period prevalence (%) | 0.37 | 0.43 | 0.24 |
| Median age at first event (years) | 45.67 | 40.95 | 56.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_COAGDEFNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEFNAS | 1.772 [1.5, 2.09] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.663 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 6334 females with D3_COAGDEFNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEFNAS | 1.758 [1.5, 2.06] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 579 out of 3194 males with D3_COAGDEFNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_COAGDEFNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.219% | 0.381% |
| 5 | 1.244% | 2.273% |
| 10 | 2.897% | 5.384% |
| 15 | 5.705% | 10.407% |
| 20 | 9.837% | 17.933% |
Relationships between endpoints
↥Index endpoint: D3_COAGDEFNAS – Other and unspecified coagulation defects
GWS hits: 28
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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