No definition available.
Disseminated intravascular coagulation [defibrination syndrome]
D3_DISSEINTRAVASCCOAG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
105 |
4. Check minimum number of eventsNone |
105 |
5. Include endpointsNone |
105 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D65-D69
Name in latin
Coagulatio intravascularis disseminata
Similar endpoints
↥List of similar endpoints to
Disseminated intravascular coagulation [defibrination syndrome]
based on the number of shared cases.
Similar with more cases:
- Coagulation defects, purpura and other haemorrhagic conditions
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1279 | 631 | 631 |
| Only index persons | 817 | 418 | 399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.83 | 59.55 | 58.04 |
| Only index persons | 56.58 | 56.34 | 56.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 53 | 46 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 49.35 | 43.31 | 56.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_DISSEINTRAVASCCOAG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 3.462 [2.16, 5.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 307 females with D3_DISSEINTRAVASCCOAG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 4.371 [2.68, 7.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 291 males with D3_DISSEINTRAVASCCOAG died.
Mortality risk
Mortality risk for people of age
years, who have D3_DISSEINTRAVASCCOAG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.317% | 0.77% |
| 5 | 2.11% | 4.787% |
| 10 | 4.958% | 11.208% |
| 15 | 8.941% | 20.685% |
| 20 | 14.772% | 33.351% |
Relationships between endpoints
↥Index endpoint: D3_DISSEINTRAVASCCOAG – Disseminated intravascular coagulation [defibrination syndrome]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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