immune system disease: A disorder resulting from an abnormality in the immune system.
Certain disorders involving the immune mechanism
DOID EFO Endpoint Browser PheWeb
D3_IMMUNEMECHANISM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
7481 |
6. Filter based on genotype QC (FinnGen only) |
7210 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Certain disorders involving the immune mechanism
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 50702 | 26913 | 23461 |
| Only index persons | 44339 | 23677 | 20662 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.71 | 0.77 | 0.66 |
| Only index persons | 0.83 | 0.87 | 0.79 |
| Median age at first event (years) | |||
| Whole population | 46.66 | 49.29 | 43.59 |
| Only index persons | 45.47 | 47.89 | 42.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7210 | 4006 | 3204 |
| Unadjusted period prevalence (%) | 1.59 | 1.57 | 1.61 |
| Median age at first event (years) | 47.24 | 47.55 | 46.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUNEMECHANISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUNEMECHANISM | 1.833 [1.67, 2.01] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.845 |
During the follow-up period (1.1.1998 — 31.12.2019), 2580 out of 16776 females with D3_IMMUNEMECHANISM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUNEMECHANISM | 1.846 [1.68, 2.02] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 2825 out of 15385 males with D3_IMMUNEMECHANISM died.
Mortality risk
Mortality risk for people of age
years, who have D3_IMMUNEMECHANISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.314% |
| 5 | 1.333% | 2.152% |
| 10 | 3.185% | 5.232% |
| 15 | 6.206% | 10.295% |
| 20 | 10.567% | 17.253% |
Relationships between endpoints
↥Index endpoint: D3_IMMUNEMECHANISM – Certain disorders involving the immune mechanism
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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